{"product_id":"mots-c","title":"MOTS-c","description":"\u003cp\u003eMOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA, discovered in 2015. Unusually for a peptide, it acts as a retrograde signal from the mitochondria to the nucleus, regulating metabolic homeostasis and cellular stress responses. Research shows MOTS-c activates the AMPK energy-sensing pathway, enhancing glucose utilization, insulin sensitivity, and fatty-acid metabolism. Studies demonstrate that it functions as an exercise mimetic: physical activity raises endogenous MOTS-c, and administration in animal models improves metabolic flexibility, reduces diet-induced obesity and insulin resistance, and counteracts age-dependent physical decline and muscle loss. Circulating MOTS-c levels fall with age, correlating with reduced metabolic and mitochondrial function, while its nuclear translocation activates antioxidant and metabolic gene programs during stress. These findings make MOTS-c a leading model compound in mitochondrial biology, metabolic health, aging, and exercise-physiology research.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor laboratory and research use only. Not for human consumption.\u003c\/em\u003e\u003c\/p\u003e","brand":"Olympix Bioscience","offers":[{"title":"10mg","offer_id":48082997969061,"sku":"VG-MOTS-10MG","price":43.99,"currency_code":"USD","in_stock":true},{"title":"40mg","offer_id":48096338378917,"sku":"OLX-MOTS-40MG","price":126.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0777\/7779\/7285\/files\/IMG-0396.png?v=1785735871","url":"https:\/\/olympixbiolabs.com\/products\/mots-c","provider":"Prime Peptides","version":"1.0","type":"link"}