MOTS-c
MOTS-c
MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA, discovered in 2015. Unusually for a peptide, it acts as a retrograde signal from the mitochondria to the nucleus, regulating metabolic homeostasis and cellular stress responses. Research shows MOTS-c activates the AMPK energy-sensing pathway, enhancing glucose utilization, insulin sensitivity, and fatty-acid metabolism. Studies demonstrate that it functions as an exercise mimetic: physical activity raises endogenous MOTS-c, and administration in animal models improves metabolic flexibility, reduces diet-induced obesity and insulin resistance, and counteracts age-dependent physical decline and muscle loss. Circulating MOTS-c levels fall with age, correlating with reduced metabolic and mitochondrial function, while its nuclear translocation activates antioxidant and metabolic gene programs during stress. These findings make MOTS-c a leading model compound in mitochondrial biology, metabolic health, aging, and exercise-physiology research.
For laboratory and research use only. Not for human consumption.
Frequently Asked Questions
Are your products third-party tested?
Yes. Every batch is independently tested for identity and purity by HPLC and mass spectrometry at U.S. accredited labs, and a Certificate of Analysis is available for each batch.
What purity can I expect?
All compounds are 99%+ purity, verified by HPLC.
How should this be stored?
Store lyophilized (freeze-dried) material cool and dry; refrigerate once reconstituted. Refer to the product details for compound-specific guidance.
How fast do you ship?
Orders generally ship within 1–2 business days in temperature-controlled, tamper-evident packaging with tracking.
Are these safe for human use?
No. All products are sold strictly for in-vitro research and laboratory use only and are not for human or animal consumption.
Reconstitution Calculator
Enter your vial size, the amount of bacteriostatic water you are adding, and your target dose to see the concentration and how many units to draw on a U-100 insulin syringe.
For in-vitro research and laboratory reference only. Not medical advice. Products are not for human or animal consumption. Calculations assume a standard U-100 insulin syringe (100 units = 1 mL).